Title |
HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR
|
---|---|
Published in |
BMC Molecular and Cell Biology, July 2007
|
DOI | 10.1186/1471-2199-8-63 |
Pubmed ID | |
Authors |
Zachary Klase, Prachee Kale, Rafael Winograd, Madhur V Gupta, Mohammad Heydarian, Reem Berro, Timothy McCaffrey, Fatah Kashanchi |
Abstract |
RNA interference (RNAi) is a regulatory mechanism conserved in higher eukaryotes. The RNAi pathway generates small interfering RNA (siRNA) or micro RNA (miRNA) from either long double stranded stretches of RNA or RNA hairpins, respectively. The siRNA or miRNA then guides an effector complex to a homologous sequence of mRNA and regulates suppression of gene expression through one of several mechanisms. The suppression of gene expression through these mechanisms serves to regulate endogenous gene expression and protect the cell from foreign nucleic acids. There is growing evidence that many viruses have developed in the context of RNAi and express either a suppressor of RNAi or their own viral miRNA. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 4% |
Netherlands | 2 | 1% |
United Kingdom | 2 | 1% |
Finland | 1 | <1% |
France | 1 | <1% |
Belgium | 1 | <1% |
Italy | 1 | <1% |
Unknown | 148 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 42 | 26% |
Researcher | 36 | 22% |
Student > Doctoral Student | 17 | 10% |
Student > Bachelor | 15 | 9% |
Student > Master | 15 | 9% |
Other | 25 | 15% |
Unknown | 12 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 89 | 55% |
Biochemistry, Genetics and Molecular Biology | 24 | 15% |
Medicine and Dentistry | 12 | 7% |
Immunology and Microbiology | 11 | 7% |
Chemistry | 4 | 2% |
Other | 6 | 4% |
Unknown | 16 | 10% |