Title |
Mineral bone disorder in chronic kidney disease: head-to-head comparison of the 5/6 nephrectomy and adenine models
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Published in |
BMC Nephrology, May 2014
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DOI | 10.1186/1471-2369-15-69 |
Pubmed ID | |
Authors |
Guaraciaba O Ferrari, Juliana C Ferreira, Raquel T Cavallari, Katia R Neves, Luciene M dos Reis, Wagner V Dominguez, Elizabeth C Oliveira, Fabiana G Graciolli, Jutta Passlick-Deetjen, Vanda Jorgetti, Rosa MA Moysés |
Abstract |
Experimental models are important to the understanding of the pathophysiology of, as well as the effects of therapy on, certain diseases. In the case of chronic kidney disease-mineral bone disorder, there are currently two models that are used in evaluating the disease: 5/6 nephrectomy (Nx) and adenine-induced renal failure (AIRF). However, the two models have never been compared in studies using animals maintained under similar conditions. Therefore, we compared these two models, focusing on the biochemical, bone histomorphometry, and vascular calcification aspects. |
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