Title |
The wide expansion of hepatitis delta virus-like ribozymes throughout trypanosomatid genomes is linked to the spreading of L1Tc/ingi clade mobile elements
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Published in |
BMC Genomics, May 2014
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DOI | 10.1186/1471-2164-15-340 |
Pubmed ID | |
Authors |
Francisco José Sánchez-Luque, Manuel Carlos López, Patricia Eugenia Carreira, Carlos Alonso, María Carmen Thomas |
Abstract |
Hepatitis Delta Virus (HDV)-like ribozymes have recently been found in many mobile elements in which they take part in a mechanism that releases intermediate RNAs from cellular co-transcripts. L1Tc in Trypanosoma cruzi is one of the elements in which such a ribozyme is located. It lies in the so-called Pr77-hallmark, a conserved region shared by retrotransposons belonging to the trypanosomatid L1Tc/ingi clade. The wide distribution of the Pr77-hallmark detected in trypanosomatid retrotransposons renders the potential catalytic activity of these elements worthy of study: their distribution might contribute to host genetic regulation at the mRNA level. Indeed, in Leishmania spp, the pervasive presence of these HDV-like ribozyme-containing mobile elements in certain 3'-untranslated regions of protein-coding genes has been linked to mRNA downregulation. |
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France | 1 | 100% |
Demographic breakdown
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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Brazil | 1 | 6% |
Unknown | 15 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 38% |
Student > Ph. D. Student | 3 | 19% |
Professor > Associate Professor | 3 | 19% |
Student > Master | 1 | 6% |
Student > Postgraduate | 1 | 6% |
Other | 0 | 0% |
Unknown | 2 | 13% |
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Chemistry | 1 | 6% |
Other | 0 | 0% |
Unknown | 2 | 13% |