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Bioavailability of transgenic microRNAs in genetically modified plants

Overview of attention for article published in Genes & Nutrition, July 2017
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2 tweeters

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Title
Bioavailability of transgenic microRNAs in genetically modified plants
Published in
Genes & Nutrition, July 2017
DOI 10.1186/s12263-017-0563-5
Pubmed ID
Authors

Jian Yang, Cecilia Primo, Ismail Elbaz-Younes, Kendal D. Hirschi

Abstract

Transgenic expression of small RNAs is a prevalent approach in agrobiotechnology for the global enhancement of plant foods. Meanwhile, emerging studies have, on the one hand, emphasized the potential of transgenic microRNAs (miRNAs) as novel dietary therapeutics and, on the other, suggested potential food safety issues if harmful miRNAs are absorbed and bioactive. For these reasons, it is necessary to evaluate the bioavailability of transgenic miRNAs in genetically modified crops. As a pilot study, two transgenic Arabidopsis lines ectopically expressing unique miRNAs were compared and contrasted with the plant bioavailable small RNA MIR2911 for digestive stability and serum bioavailability. The expression levels of these transgenic miRNAs in Arabidopsis were found to be comparable to that of MIR2911 in fresh tissues. Assays of digestive stability in vitro and in vivo suggested the transgenic miRNAs and MIR2911 had comparable resistance to degradation. Healthy mice consuming diets rich in Arabidopsis lines expressing these miRNAs displayed MIR2911 in the bloodstream but no detectable levels of the transgenic miRNAs. These preliminary results imply digestive stability and high expression levels of miRNAs in plants do not readily equate to bioavailability. This initial work suggests novel engineering strategies be employed to enhance miRNA bioavailability when attempting to use transgenic foods as a delivery platform.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 17%
Researcher 4 14%
Student > Bachelor 3 10%
Student > Ph. D. Student 3 10%
Other 2 7%
Other 2 7%
Unknown 10 34%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 28%
Biochemistry, Genetics and Molecular Biology 5 17%
Medicine and Dentistry 2 7%
Engineering 1 3%
Unknown 13 45%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2018.
All research outputs
#9,679,945
of 12,612,351 outputs
Outputs from Genes & Nutrition
#227
of 318 outputs
Outputs of similar age
#178,147
of 264,249 outputs
Outputs of similar age from Genes & Nutrition
#1
of 1 outputs
Altmetric has tracked 12,612,351 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 318 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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