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European Adrenal Insufficiency Registry (EU-AIR): a comparative observational study of glucocorticoid replacement therapy

Overview of attention for article published in BMC Endocrine Disorders, May 2014
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Title
European Adrenal Insufficiency Registry (EU-AIR): a comparative observational study of glucocorticoid replacement therapy
Published in
BMC Endocrine Disorders, May 2014
DOI 10.1186/1472-6823-14-40
Pubmed ID
Authors

Bertil Ekman, David Fitts, Claudio Marelli, Robert D Murray, Marcus Quinkler, Pierre MJ Zelissen

Abstract

Increased morbidity and mortality associated with conventional glucocorticoid replacement therapy for primary adrenal insufficiency (primary AI; estimated prevalence 93-140/million), secondary AI (estimated prevalence, 150-280/million, respectively) or congenital adrenal hyperplasia (estimated prevalence, approximately 65/million) may be due to the inability of typical glucocorticoid treatment regimens to reproduce the normal circadian profile of plasma cortisol. A once-daily modified-release formulation of hydrocortisone has been developed to provide a plasma cortisol profile that better mimics the daytime endogenous profile of cortisol. Here, we describe the protocol for the European Adrenal Insufficiency Registry (EU-AIR), an observational study to assess the long-term safety of modified-release hydrocortisone compared with conventional glucocorticoid replacement therapies in routine clinical practice (ClinicalTrials.gov identifier: NCT01661387).

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 11 17%
Researcher 10 15%
Student > Bachelor 9 14%
Student > Master 9 14%
Student > Ph. D. Student 5 8%
Other 6 9%
Unknown 15 23%
Readers by discipline Count As %
Medicine and Dentistry 35 54%
Biochemistry, Genetics and Molecular Biology 4 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Chemistry 2 3%
Nursing and Health Professions 1 2%
Other 5 8%
Unknown 15 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2014.
All research outputs
#20,229,658
of 22,755,127 outputs
Outputs from BMC Endocrine Disorders
#604
of 745 outputs
Outputs of similar age
#193,090
of 227,219 outputs
Outputs of similar age from BMC Endocrine Disorders
#10
of 13 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 745 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.