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A case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies

Overview of attention for article published in Journal of Clinical Movement Disorders, May 2017
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Title
A case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies
Published in
Journal of Clinical Movement Disorders, May 2017
DOI 10.1186/s40734-017-0053-3
Pubmed ID
Authors

Theresa E. Pancotto, John H. Rossmeisl

Abstract

The stiff person syndrome (SPS) is a rare and debilitating autoimmune disorder with an unknown pathogenesis and variable clinical presentation that can present a diagnostic challenge. Although entities that clinically mimic stiff-person spectrum disorders (SPSD) have manifested in horses, they have not been reported in dogs. We describe a 2-year-old beagle dog presented for progressive attacks of muscular rigidity and lordosis with superimposed spasms of the appendicular muscles triggered by tactile stimulation which resulted in marked gait impairment. Resting electromyography revealed continuous motor unit activity in the axial musculature. Compared to age-matched healthy beagle dogs, this patient had elevated glutamic acid decarboxylase antibody concentrations in serum and cerebrospinal fluid. This dog presented with phenotypic, electrodiagnostic, and immunologic criterion consistent with an SPSD, including elevated anti-GAD antibody titers, which we have termed the "stiff dog syndrome (SDS)". Durable clinical improvement was achieved with symptomatic and immunosuppressive treatments including baclofen, gabapentin, prednisone, and intravenous immunoglobulin.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 16%
Student > Postgraduate 3 12%
Student > Doctoral Student 3 12%
Lecturer 2 8%
Other 2 8%
Other 7 28%
Unknown 4 16%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 9 36%
Neuroscience 4 16%
Medicine and Dentistry 3 12%
Sports and Recreations 2 8%
Unspecified 1 4%
Other 2 8%
Unknown 4 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2017.
All research outputs
#20,441,465
of 22,996,001 outputs
Outputs from Journal of Clinical Movement Disorders
#57
of 64 outputs
Outputs of similar age
#270,567
of 310,786 outputs
Outputs of similar age from Journal of Clinical Movement Disorders
#5
of 6 outputs
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