Title |
Intratumoral delivery of recombinant vaccinia virus encoding for ErbB2/Neu inhibits the growth of salivary gland carcinoma cells
|
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Published in |
Journal of Translational Medicine, May 2014
|
DOI | 10.1186/1479-5876-12-122 |
Pubmed ID | |
Authors |
Laura Masuelli, Massimo Fantini, Monica Benvenuto, Pamela Sacchetti, Maria Gabriella Giganti, Ilaria Tresoldi, Paolo Lido, Florigio Lista, Federica Cavallo, Patrizia Nanni, Jeffrey Schlom, Andrea Modesti, Roberto Bei |
Abstract |
The antitumor activity induced by intratumoral vaccination with poxvirus expressing a tumor antigen was shown to be superior to that induced by subcutaneous vaccination. Salivary gland carcinomas overexpress ErbB2. Trastuzumab, a monoclonal antibody to ErbB2, was proposed for salivary gland tumors treatment. We explored the effectiveness of intratumoral vaccination with the recombinant vaccinia virus ErbB2/Neu (rV-neuT) vaccine in hampering the growth of transplanted Neu-overexpressing BALB-neuT salivary gland cancer cells (SALTO) in BALB-neuT mice. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 16% |
Researcher | 3 | 16% |
Professor > Associate Professor | 3 | 16% |
Student > Master | 2 | 11% |
Student > Doctoral Student | 2 | 11% |
Other | 4 | 21% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 4 | 21% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Medicine and Dentistry | 2 | 11% |
Agricultural and Biological Sciences | 2 | 11% |
Nursing and Health Professions | 1 | 5% |
Other | 2 | 11% |
Unknown | 6 | 32% |