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Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension

Overview of attention for article published in Journal of Headache & Pain, November 2009
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  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Citations

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120 Mendeley
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Title
Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension
Published in
Journal of Headache & Pain, November 2009
DOI 10.1007/s10194-009-0169-4
Pubmed ID
Authors

Denys Fontaine, Yves Lazorthes, Patrick Mertens, Serge Blond, Gilles Géraud, Nelly Fabre, Malou Navez, Christian Lucas, Francois Dubois, Sebastien Gonfrier, Philippe Paquis, Michel Lantéri-Minet

Abstract

Chronic cluster headache (CCH) is a disabling primary headache, considering the severity and frequency of pain attacks. Deep brain stimulation (DBS) has been used to treat severe refractory CCH, but assessment of its efficacy has been limited to open studies. We performed a prospective crossover, double-blind, multicenter study assessing the efficacy and safety of unilateral hypothalamic DBS in 11 patients with severe refractory CCH. The randomized phase compared active and sham stimulation during 1-month periods, and was followed by a 1-year open phase. The severity of CCH was assessed by the weekly attacks frequency (primary outcome), pain intensity,sumatriptan injections, emotional impact (HAD) and quality of life (SF12). Tolerance was assessed by active surveillance of behavior, homeostatic and hormonal functions.During the randomized phase, no significant change in primary and secondary outcome measures was observed between active and sham stimulation. At the end of the open phase, 6/11 responded to the chronic stimulation(weekly frequency of attacks decrease [50%), including three pain-free patients. There were three serious adverse events, including subcutaneous infection, transient loss of consciousness and micturition syncopes. No significant change in hormonal functions or electrolytic balance was observed. Randomized phase findings of this study did not support the efficacy of DBS in refractory CCH, but open phase findings suggested long-term efficacy in more than 50% patients, confirming previous data, without high morbidity. Discrepancy between these findings justifies additional controlled studies (clinicaltrials.gov number NCT00662935).

Mendeley readers

The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Italy 1 <1%
Unknown 118 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 23%
Student > Ph. D. Student 13 11%
Other 13 11%
Student > Master 12 10%
Student > Bachelor 9 8%
Other 26 22%
Unknown 20 17%
Readers by discipline Count As %
Medicine and Dentistry 49 41%
Neuroscience 18 15%
Agricultural and Biological Sciences 5 4%
Engineering 4 3%
Nursing and Health Professions 3 3%
Other 11 9%
Unknown 30 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2015.
All research outputs
#4,866,091
of 17,360,236 outputs
Outputs from Journal of Headache & Pain
#429
of 1,069 outputs
Outputs of similar age
#22,718
of 76,846 outputs
Outputs of similar age from Journal of Headache & Pain
#2
of 6 outputs
Altmetric has tracked 17,360,236 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,069 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,846 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.