↓ Skip to main content

Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension

Overview of attention for article published in The Journal of Headache and Pain, November 2009
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

dimensions_citation
214 Dimensions

Readers on

mendeley
158 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension
Published in
The Journal of Headache and Pain, November 2009
DOI 10.1007/s10194-009-0169-4
Pubmed ID
Authors

Denys Fontaine, Yves Lazorthes, Patrick Mertens, Serge Blond, Gilles Géraud, Nelly Fabre, Malou Navez, Christian Lucas, Francois Dubois, Sebastien Gonfrier, Philippe Paquis, Michel Lantéri-Minet

Abstract

Chronic cluster headache (CCH) is a disabling primary headache, considering the severity and frequency of pain attacks. Deep brain stimulation (DBS) has been used to treat severe refractory CCH, but assessment of its efficacy has been limited to open studies. We performed a prospective crossover, double-blind, multicenter study assessing the efficacy and safety of unilateral hypothalamic DBS in 11 patients with severe refractory CCH. The randomized phase compared active and sham stimulation during 1-month periods, and was followed by a 1-year open phase. The severity of CCH was assessed by the weekly attacks frequency (primary outcome), pain intensity,sumatriptan injections, emotional impact (HAD) and quality of life (SF12). Tolerance was assessed by active surveillance of behavior, homeostatic and hormonal functions.During the randomized phase, no significant change in primary and secondary outcome measures was observed between active and sham stimulation. At the end of the open phase, 6/11 responded to the chronic stimulation(weekly frequency of attacks decrease [50%), including three pain-free patients. There were three serious adverse events, including subcutaneous infection, transient loss of consciousness and micturition syncopes. No significant change in hormonal functions or electrolytic balance was observed. Randomized phase findings of this study did not support the efficacy of DBS in refractory CCH, but open phase findings suggested long-term efficacy in more than 50% patients, confirming previous data, without high morbidity. Discrepancy between these findings justifies additional controlled studies (clinicaltrials.gov number NCT00662935).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Italy 1 <1%
Unknown 156 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 30 19%
Student > Ph. D. Student 17 11%
Student > Master 17 11%
Other 14 9%
Student > Bachelor 12 8%
Other 31 20%
Unknown 37 23%
Readers by discipline Count As %
Medicine and Dentistry 59 37%
Neuroscience 22 14%
Agricultural and Biological Sciences 5 3%
Engineering 5 3%
Nursing and Health Professions 4 3%
Other 16 10%
Unknown 47 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2023.
All research outputs
#4,698,247
of 24,865,967 outputs
Outputs from The Journal of Headache and Pain
#525
of 1,500 outputs
Outputs of similar age
#25,554
of 178,287 outputs
Outputs of similar age from The Journal of Headache and Pain
#1
of 6 outputs
Altmetric has tracked 24,865,967 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,500 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.9. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 178,287 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them