↓ Skip to main content

Expression and pathological effects of periostin in human osteoarthritis cartilage

Overview of attention for article published in BMC Musculoskeletal Disorders, August 2015
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)

Mentioned by

1 patent


41 Dimensions

Readers on

54 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Expression and pathological effects of periostin in human osteoarthritis cartilage
Published in
BMC Musculoskeletal Disorders, August 2015
DOI 10.1186/s12891-015-0682-3
Pubmed ID

Ryota Chijimatsu, Yasuo Kunugiza, Yoshiaki Taniyama, Norimasa Nakamura, Tetsuya Tomita, Hideki Yoshikawa


Osteoarthritis (OA) is one of the most common joint diseases in elderly people, however, the underlying mechanism of OA pathogenesis is not completely clear. Periostin, the extracellular protein, has been shown by cDNA array analysis to be highly expressed in OA, but its function is not fully understood. The purpose of this study was to examine the expression and function of periostin in human OA. Human cartilage and synovia samples were used for the analysis of periostin expression and function. The human cartilage samples were obtained from the knees of patients undergoing total knee arthroplasty as OA samples and from the femoral bone head of patients with femoral neck fracture as control samples. Quantitative RT-PCR, ELISA, and immunohistochemistry were used for analysis of periostin expression in cartilage and synovia. Human primary chondrocytes isolated from control cartilage were stimulated by periostin, and the alteration of OA related gene expression was examined using quantitative RT-PCR. Immunocytochemistry of p65 was performed for the analysis of nuclear factor kappa B (NFκB) activation. The periostin mRNA was significantly higher in OA cartilage than in control cartilage. Immunohistochemical analysis of periostin showed that the main positive signal was localized in chondrocytes and their periphery matrix near the erosive area, with less immunoreactivity in deeper zones. There was positive correlation between Mankin score and periostin immunoreactivity. The periostin expression was also detected in the fibrotic cartilage and tissue of subchondral bone. In cultured human chondrocytes, periostin induced the expression of interleukin (IL)-6, IL-8, matrix metalloproteinase (MMP)-1, MMP-3, MMP-13, and nitric oxide synthase-2 (NOS2) in a dose- and time-dependent manner. The activation of NFκB signaling was recognized by the nuclear translocation of p65. Periostin-induced upregulation of these genes was suppressed by NFκB inactivation in chondrocytes. Periostin was upregulated in OA cartilage, and it may amplify inflammatory events and accelerate OA pathology.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
United Kingdom 1 2%
France 1 2%
Unknown 51 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 24%
Student > Ph. D. Student 9 17%
Student > Master 9 17%
Student > Postgraduate 4 7%
Professor > Associate Professor 3 6%
Other 5 9%
Unknown 11 20%
Readers by discipline Count As %
Medicine and Dentistry 11 20%
Agricultural and Biological Sciences 9 17%
Biochemistry, Genetics and Molecular Biology 6 11%
Engineering 4 7%
Immunology and Microbiology 2 4%
Other 7 13%
Unknown 15 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2020.
All research outputs
of 17,635,820 outputs
Outputs from BMC Musculoskeletal Disorders
of 3,315 outputs
Outputs of similar age
of 278,544 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
of 1 outputs
Altmetric has tracked 17,635,820 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,315 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,544 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them