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In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis

Overview of attention for article published in BMC Systems Biology, May 2014
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Title
In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis
Published in
BMC Systems Biology, May 2014
DOI 10.1186/1752-0509-8-54
Pubmed ID
Authors

Eleftherios Ouzounoglou, Dimitrios Kalamatianos, Evangelia Emmanouilidou, Maria Xilouri, Leonidas Stefanis, Kostas Vekrellis, Elias S Manolakos

Abstract

Alpha-synuclein (ASYN) is central in Parkinson's disease (PD) pathogenesis. Converging pieces of evidence suggest that the levels of ASYN expression play a critical role in both familial and sporadic Parkinson's disease. ASYN fibrils are the main component of inclusions called Lewy Bodies (LBs) which are found mainly in the surviving neurons of the substantia nigra. Despite the accumulated knowledge regarding the involvement of ASYN in molecular mechanisms underlying the development of PD, there is much information missing which prevents understanding the causes of the disease and how to stop its progression.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 2 3%
Luxembourg 1 2%
Unknown 57 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 28%
Student > Bachelor 12 20%
Researcher 7 12%
Student > Doctoral Student 3 5%
Student > Postgraduate 3 5%
Other 9 15%
Unknown 9 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 27%
Biochemistry, Genetics and Molecular Biology 12 20%
Neuroscience 8 13%
Computer Science 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 10 17%
Unknown 7 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2014.
All research outputs
#15,300,431
of 22,755,127 outputs
Outputs from BMC Systems Biology
#644
of 1,142 outputs
Outputs of similar age
#133,480
of 226,936 outputs
Outputs of similar age from BMC Systems Biology
#16
of 30 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,142 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,936 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.