Title |
In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis
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Published in |
BMC Systems Biology, May 2014
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DOI | 10.1186/1752-0509-8-54 |
Pubmed ID | |
Authors |
Eleftherios Ouzounoglou, Dimitrios Kalamatianos, Evangelia Emmanouilidou, Maria Xilouri, Leonidas Stefanis, Kostas Vekrellis, Elias S Manolakos |
Abstract |
Alpha-synuclein (ASYN) is central in Parkinson's disease (PD) pathogenesis. Converging pieces of evidence suggest that the levels of ASYN expression play a critical role in both familial and sporadic Parkinson's disease. ASYN fibrils are the main component of inclusions called Lewy Bodies (LBs) which are found mainly in the surviving neurons of the substantia nigra. Despite the accumulated knowledge regarding the involvement of ASYN in molecular mechanisms underlying the development of PD, there is much information missing which prevents understanding the causes of the disease and how to stop its progression. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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India | 2 | 3% |
Luxembourg | 1 | 2% |
Unknown | 57 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 28% |
Student > Bachelor | 12 | 20% |
Researcher | 7 | 12% |
Student > Doctoral Student | 3 | 5% |
Student > Postgraduate | 3 | 5% |
Other | 9 | 15% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 12 | 20% |
Neuroscience | 8 | 13% |
Computer Science | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 10 | 17% |
Unknown | 7 | 12% |