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https://t.co/4bgfBq5muG "Thus, downregulation of Nr0b2 is consistent with statins acting as ligands of vitamin D receptor (VDR)." "Interestingly, it has been hypothesised that statins, or some of their derived metabolites, could be VDR agonists."
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https://t.co/4bgfBq5muG "Interestingly, differential affinity of pravastatin and atorvastatin to CAR and PXR may explain the contrasting diabetogenic character of both drugs."
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https://t.co/4bgfBq5muG "For this study, two statins were used for their different physiochemical properties to minimise the drug selection bias: atorvastatin is lipophilic while pravastatin is hydrophilic."