Title |
Combined immunization using DNA-Sm14 and DNA-Hsp65 increases CD8+ memory T cells, reduces chronic pathology and decreases egg viability during Schistosoma mansoniinfection
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Published in |
BMC Infectious Diseases, May 2014
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DOI | 10.1186/1471-2334-14-263 |
Pubmed ID | |
Authors |
Milena Sobral Espíndola, Fabiani Gai Frantz, Luana Silva Soares, Ana Paula Masson, Cristiane Tefé-Silva, Claudia Silva Bitencourt, Sérgio Costa Oliveira, Vanderlei Rodrigues, Simone Gusmão Ramos, Célio Lopes Silva, Lúcia Helena Faccioli |
Abstract |
Schistosomiasis is one of the most important neglected diseases found in developing countries and affects 249 million people worldwide. The development of an efficient vaccination strategy is essential for the control of this disease. Previous work showed partial protection induced by DNA-Sm14 against Schistosoma mansoni infection, whereas DNA-Hsp65 showed immunostimulatory properties against infectious diseases, autoimmune diseases, cancer and antifibrotic properties in an egg-induced granuloma model. |
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United Kingdom | 1 | 33% |
Germany | 1 | 33% |
Venezuela, Bolivarian Republic of | 1 | 33% |
Demographic breakdown
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
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Japan | 1 | 3% |
Unknown | 32 | 97% |
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Student > Master | 6 | 18% |
Student > Ph. D. Student | 5 | 15% |
Researcher | 4 | 12% |
Lecturer | 2 | 6% |
Professor > Associate Professor | 2 | 6% |
Other | 5 | 15% |
Unknown | 9 | 27% |
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Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Other | 2 | 6% |
Unknown | 11 | 33% |