Title |
Evaluating the evidence for macrophage presence in skeletal muscle and its relation to insulin resistance in obese mice and humans: a systematic review protocol
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Published in |
BMC Research Notes, August 2017
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DOI | 10.1186/s13104-017-2686-6 |
Pubmed ID | |
Authors |
Meha Bhatt, Srikesh Rudrapatna, Laura Banfield, Rachel Bierbrier, Pei-Wen Wang, Kuan-Wen Wang, Lehana Thabane, M. Constantine Samaan |
Abstract |
The current global rates of obesity and type 2 diabetes are staggering. In order to implement effective management strategies, it is imperative to understand the mechanisms of obesity-induced insulin resistance and diabetes. Macrophage infiltration and inflammation of the adipose tissue in obesity is a well-established paradigm, yet the role of macrophages in muscle inflammation, insulin resistance and diabetes is not adequately studied. In this systematic review, we will examine the evidence for the presence of macrophages in skeletal muscle of obese humans and mice, and will assess the association between muscle macrophages and insulin resistance. We will identify published studies that address muscle macrophage content and phenotype, and its association with insulin resistance. We will search MEDLINE/PubMed, EMBASE, and Web of Science for eligible studies. Grey literature will be searched in ProQuest. Quality assessment will be conducted using the Systematic Review Centre for Laboratory Animal Experimentation risk of bias Tool for animal studies. The findings of this systematic review will shed light on immune-metabolic crosstalk in obesity, and allow the consideration of targeted therapies to modulate muscle macrophages in the treatment and prevention of diabetes. The review will be published in a peer-reviewed journal and presented at conferences. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 20% |
Student > Bachelor | 7 | 20% |
Researcher | 4 | 11% |
Librarian | 3 | 9% |
Student > Ph. D. Student | 2 | 6% |
Other | 3 | 9% |
Unknown | 9 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 23% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Nursing and Health Professions | 5 | 14% |
Psychology | 2 | 6% |
Arts and Humanities | 1 | 3% |
Other | 2 | 6% |
Unknown | 12 | 34% |