Title |
Network topology-based detection of differential gene regulation and regulatory switches in cell metabolism and signaling
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Published in |
BMC Systems Biology, May 2014
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DOI | 10.1186/1752-0509-8-56 |
Pubmed ID | |
Authors |
Rosario M Piro, Stefan Wiesberg, Gunnar Schramm, Nico Rebel, Marcus Oswald, Roland Eils, Gerhard Reinelt, Rainer König |
Abstract |
Common approaches to pathway analysis treat pathways merely as lists of genes disregarding their topological structures, that is, ignoring the genes' interactions on which a pathway's cellular function depends. In contrast, PathWave has been developed for the analysis of high-throughput gene expression data that explicitly takes the topology of networks into account to identify both global dysregulation of and localized (switch-like) regulatory shifts within metabolic and signaling pathways. For this purpose, it applies adjusted wavelet transforms on optimized 2D grid representations of curated pathway maps. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 5% |
Germany | 1 | 1% |
Australia | 1 | 1% |
Turkey | 1 | 1% |
China | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 68 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 25% |
Researcher | 16 | 21% |
Student > Master | 6 | 8% |
Professor | 5 | 6% |
Student > Bachelor | 4 | 5% |
Other | 15 | 19% |
Unknown | 12 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 40% |
Biochemistry, Genetics and Molecular Biology | 12 | 16% |
Computer Science | 7 | 9% |
Engineering | 4 | 5% |
Medicine and Dentistry | 4 | 5% |
Other | 7 | 9% |
Unknown | 12 | 16% |