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4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells

Overview of attention for article published in Genome Biology (Online Edition), May 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)

Mentioned by

news
1 news outlet
twitter
10 tweeters
patent
3 patents
googleplus
1 Google+ user
q&a
2 Q&A threads

Citations

dimensions_citation
130 Dimensions

Readers on

mendeley
184 Mendeley
citeulike
3 CiteULike
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Title
4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells
Published in
Genome Biology (Online Edition), May 2014
DOI 10.1186/gb-2014-15-5-r69
Pubmed ID
Authors

Gilad Fuchs, Yoav Voichek, Sima Benjamin, Shlomit Gilad, Ido Amit, Moshe Oren

Abstract

Although transcriptional elongation by RNA polymerase II is coupled with many RNA-related processes, genomewide elongation rates remain unknown. We describe a method, called 4sUDRB-seq, based on reversible inhibition of transcription elongation coupled with tagging newly transcribed RNA with 4-thiouridine and high throughput sequencing to measure simultaneously with high confidence genome-wide transcription elongation rates in cells. We find that most genes are transcribed at about 3.5 Kb/min, with elongation rates varying between 2 Kb/min and 6 Kb/min. 4sUDRB-seq can facilitate genomewide exploration of the involvement of specific elongation factors in transcription and the contribution of deregulated transcription elongation to various pathologies.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
Korea, Republic of 1 <1%
Austria 1 <1%
Sweden 1 <1%
Germany 1 <1%
Israel 1 <1%
Japan 1 <1%
United States 1 <1%
Luxembourg 1 <1%
Other 0 0%
Unknown 174 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 54 29%
Researcher 43 23%
Student > Master 24 13%
Student > Bachelor 13 7%
Professor 9 5%
Other 24 13%
Unknown 17 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 78 42%
Agricultural and Biological Sciences 69 38%
Medicine and Dentistry 7 4%
Computer Science 2 1%
Chemistry 2 1%
Other 6 3%
Unknown 20 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2021.
All research outputs
#1,144,055
of 21,735,696 outputs
Outputs from Genome Biology (Online Edition)
#1,007
of 4,002 outputs
Outputs of similar age
#12,197
of 204,829 outputs
Outputs of similar age from Genome Biology (Online Edition)
#1
of 3 outputs
Altmetric has tracked 21,735,696 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,002 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.7. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them