Title |
Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunity
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Published in |
Cell & Bioscience, May 2014
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DOI | 10.1186/2045-3701-4-25 |
Pubmed ID | |
Authors |
Fang-Hsuean Liao, Jr-Wen Shui, En-Wei Hsing, Wan-Yi Hsiao, Yu-Chun Lin, Yi-Chiao Chan, Tse-Hua Tan, Ching-Yu Huang |
Abstract |
Protein phosphates 4 (PP4), encoded by the ppp4c gene, is a ubiquitously expressed phosphatase that has been implicated in the regulation of cytokine signaling and lymphocyte survival; recent reports suggest that PP4 may be involved in pre-TCR signaling and B cell development. However, whether PP4 also modulates the functions of peripheral T cells has not been investigated due to the lack of a suitable in vivo model. Treg cells are a specialized subset of CD4 helper T cells that can suppress the proliferation of activated effector T cells. In the absence of this negative regulation, autoimmune syndromes and inflammatory diseases, such as human Crohn's disease, will arise. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 4% |
United States | 1 | 4% |
France | 1 | 4% |
Unknown | 20 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 22% |
Student > Master | 4 | 17% |
Researcher | 4 | 17% |
Student > Postgraduate | 2 | 9% |
Student > Bachelor | 2 | 9% |
Other | 2 | 9% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 35% |
Medicine and Dentistry | 3 | 13% |
Immunology and Microbiology | 3 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Neuroscience | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 22% |