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Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunity

Overview of attention for article published in Cell & Bioscience, May 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
11 Dimensions

Readers on

mendeley
23 Mendeley
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Title
Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunity
Published in
Cell & Bioscience, May 2014
DOI 10.1186/2045-3701-4-25
Pubmed ID
Authors

Fang-Hsuean Liao, Jr-Wen Shui, En-Wei Hsing, Wan-Yi Hsiao, Yu-Chun Lin, Yi-Chiao Chan, Tse-Hua Tan, Ching-Yu Huang

Abstract

Protein phosphates 4 (PP4), encoded by the ppp4c gene, is a ubiquitously expressed phosphatase that has been implicated in the regulation of cytokine signaling and lymphocyte survival; recent reports suggest that PP4 may be involved in pre-TCR signaling and B cell development. However, whether PP4 also modulates the functions of peripheral T cells has not been investigated due to the lack of a suitable in vivo model. Treg cells are a specialized subset of CD4 helper T cells that can suppress the proliferation of activated effector T cells. In the absence of this negative regulation, autoimmune syndromes and inflammatory diseases, such as human Crohn's disease, will arise.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 4%
United States 1 4%
France 1 4%
Unknown 20 87%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 22%
Student > Ph. D. Student 5 22%
Student > Master 4 17%
Student > Bachelor 2 9%
Student > Postgraduate 2 9%
Other 2 9%
Unknown 3 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 35%
Medicine and Dentistry 3 13%
Immunology and Microbiology 3 13%
Biochemistry, Genetics and Molecular Biology 2 9%
Neuroscience 2 9%
Other 1 4%
Unknown 4 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2014.
All research outputs
#458,077
of 3,752,295 outputs
Outputs from Cell & Bioscience
#4
of 63 outputs
Outputs of similar age
#13,928
of 94,494 outputs
Outputs of similar age from Cell & Bioscience
#1
of 4 outputs
Altmetric has tracked 3,752,295 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 63 research outputs from this source. They receive a mean Attention Score of 2.2. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,494 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them