Title |
EPAS1 gene variants are associated with sprint/power athletic performance in two cohorts of European athletes
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Published in |
BMC Genomics, May 2014
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DOI | 10.1186/1471-2164-15-382 |
Pubmed ID | |
Authors |
Sarah Voisin, Pawel Cieszczyk, Vladimir P Pushkarev, Dmitry A Dyatlov, Boris F Vashlyayev, Vladimir A Shumaylov, Agnieszka Maciejewska-Karlowska, Marek Sawczuk, Lidia Skuza, Zbigniew Jastrzebski, David J Bishop, Nir Eynon |
Abstract |
The endothelial PAS domain protein 1 (EPAS1) activates genes that are involved in erythropoiesis and angiogenesis, thus favoring a better delivery of oxygen to the tissues and is a plausible candidate to influence athletic performance. Using innovative statistical methods we compared genotype distributions and interactions of EPAS1 SNPs rs1867785, rs11689011, rs895436, rs4035887 and rs1867782 between sprint/power athletes (n=338), endurance athletes (n=254), and controls (603) in Polish and Russian samples. We also examined the association between these SNPs and the athletes' competition level ('elite' and 'sub-elite' level). Genotyping was performed by either Real-Time PCR or by Single-Base Extension (SBE) method. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 25% |
United Kingdom | 3 | 25% |
Australia | 2 | 17% |
Unknown | 4 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 6 | 50% |
Members of the public | 5 | 42% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Singapore | 1 | 1% |
Unknown | 72 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 15% |
Researcher | 9 | 12% |
Student > Bachelor | 8 | 11% |
Student > Master | 6 | 8% |
Student > Doctoral Student | 6 | 8% |
Other | 14 | 19% |
Unknown | 20 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Sports and Recreations | 13 | 18% |
Agricultural and Biological Sciences | 12 | 16% |
Biochemistry, Genetics and Molecular Biology | 6 | 8% |
Medicine and Dentistry | 6 | 8% |
Nursing and Health Professions | 4 | 5% |
Other | 8 | 11% |
Unknown | 25 | 34% |