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The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress

Overview of attention for article published in Molecular Brain, August 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

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3 tweeters
patent
1 patent

Citations

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31 Dimensions

Readers on

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84 Mendeley
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Title
The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress
Published in
Molecular Brain, August 2017
DOI 10.1186/s13041-017-0318-7
Pubmed ID
Authors

Qi-xin Shi, Liu-kun Yang, Wen-long Shi, Lu Wang, Shi-meng Zhou, Shao-yu Guan, Ming-gao Zhao, Qi Yang

Abstract

The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid receptor, whose exact role in anxiety remains unknown. The present study was conducted to explore the possible mechanisms by which GPR55 regulates anxiety and to evaluate the effectiveness of O-1602 in the treatment of anxiety-like symptoms. Mice were exposed to two types of acute stressors: restraint and forced swimming. Anxiety behavior was evaluated using the elevated plus maze and the open field test. We found that O-1602 alleviated anxiety-like behavior in acutely stressed mice. We used lentiviral shRNA to selective ly knockdown GPR55 in the medial orbital cortex and found that knockdown of GPR55 abolished the anxiolytic effect of O-1602. We also used Y-27632, a specific inhibitor of ROCK, and U73122, an inhibitor of PLC, and found that both inhibitors attenuated the effectiveness of O-1602. Western blot analysis revealed that O-1602 downregulated the expression of GluA1 and GluN2A in mice. Taken together, these results suggest that GPR55 plays an important role in anxiety and O-1602 may have therapeutic potential in treating anxiety-like symptoms.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 84 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 23 27%
Student > Ph. D. Student 10 12%
Student > Master 10 12%
Researcher 8 10%
Student > Postgraduate 5 6%
Other 10 12%
Unknown 18 21%
Readers by discipline Count As %
Neuroscience 13 15%
Medicine and Dentistry 11 13%
Biochemistry, Genetics and Molecular Biology 7 8%
Agricultural and Biological Sciences 7 8%
Psychology 5 6%
Other 13 15%
Unknown 28 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2022.
All research outputs
#5,424,926
of 21,244,293 outputs
Outputs from Molecular Brain
#243
of 1,052 outputs
Outputs of similar age
#84,121
of 289,174 outputs
Outputs of similar age from Molecular Brain
#1
of 2 outputs
Altmetric has tracked 21,244,293 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,052 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,174 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them