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Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome

Overview of attention for article published in Arthritis Research & Therapy, April 2006
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Title
Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome
Published in
Arthritis Research & Therapy, April 2006
DOI 10.1186/ar1950
Pubmed ID
Authors

Roland Staud

Abstract

Fibromyalgia (FM) pain is frequent in the general population but its pathogenesis is only poorly understood. Many recent studies have emphasized the role of central nervous system pain processing abnormalities in FM, including central sensitization and inadequate pain inhibition. However, increasing evidence points towards peripheral tissues as relevant contributors of painful impulse input that might either initiate or maintain central sensitization, or both. It is well known that persistent or intense nociception can lead to neuroplastic changes in the spinal cord and brain, resulting in central sensitization and pain. This mechanism represents a hallmark of FM and many other chronic pain syndromes, including irritable bowel syndrome, temporomandibular disorder, migraine, and low back pain. Importantly, after central sensitization has been established only minimal nociceptive input is required for the maintenance of the chronic pain state. Additional factors, including pain related negative affect and poor sleep have been shown to significantly contribute to clinical FM pain. Better understanding of these mechanisms and their relationship to central sensitization and clinical pain will provide new approaches for the prevention and treatment of FM and other chronic pain syndromes.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 251 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 <1%
United States 2 <1%
Australia 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Germany 1 <1%
Greece 1 <1%
Israel 1 <1%
Unknown 241 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 13%
Student > Master 32 13%
Researcher 31 12%
Student > Bachelor 23 9%
Student > Postgraduate 22 9%
Other 74 29%
Unknown 37 15%
Readers by discipline Count As %
Medicine and Dentistry 81 32%
Psychology 30 12%
Nursing and Health Professions 24 10%
Agricultural and Biological Sciences 21 8%
Neuroscience 9 4%
Other 37 15%
Unknown 49 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2015.
All research outputs
#22,759,452
of 25,373,627 outputs
Outputs from Arthritis Research & Therapy
#3,132
of 3,381 outputs
Outputs of similar age
#82,221
of 84,516 outputs
Outputs of similar age from Arthritis Research & Therapy
#22
of 22 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.