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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b
|
|---|---|
| Published in |
Theoretical Biology and Medical Modelling, January 2006
|
| DOI | 10.1186/1742-4682-3-1 |
| Pubmed ID | |
| Authors |
Trevor G Marshall, Robert E Lee, Frances E Marshall |
| Abstract |
There have been indications that common Angiotensin Receptor Blockers (ARBs) may be exerting anti-inflammatory actions by directly modulating the immune system. We decided to use molecular modelling to rapidly assess which of the potential targets might justify the expense of detailed laboratory validation. We first studied the VDR nuclear receptor, which is activated by the secosteroid hormone 1,25-dihydroxyvitamin-D. This receptor mediates the expression of regulators as ubiquitous as GnRH (Gonadatrophin hormone releasing hormone) and the Parathyroid Hormone (PTH). Additionally we examined Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma), which affects the function of phagocytic cells, and the C-CChemokine Receptor, type 2b, (CCR2b), which recruits monocytes to the site of inflammatory immune challenge. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 134 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 8% |
| Researcher | 10 | 7% |
| Professor > Associate Professor | 7 | 5% |
| Student > Ph. D. Student | 7 | 5% |
| Other | 6 | 4% |
| Other | 11 | 8% |
| Unknown | 88 | 63% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 11% |
| Agricultural and Biological Sciences | 12 | 9% |
| Chemistry | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Biochemistry, Genetics and Molecular Biology | 3 | 2% |
| Other | 6 | 4% |
| Unknown | 91 | 65% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2023.
All research outputs
#7,243,972
of 25,483,400 outputs
Outputs from Theoretical Biology and Medical Modelling
#85
of 287 outputs
Outputs of similar age
#36,927
of 173,138 outputs
Outputs of similar age from Theoretical Biology and Medical Modelling
#2
of 7 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 287 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,138 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.