Title |
Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer
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Published in |
BMC Cancer, April 2014
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DOI | 10.1186/1471-2407-14-237 |
Pubmed ID | |
Authors |
Annika N Alexopoulou, Colan M Ho-Yen, Vassilis Papalazarou, George Elia, J Louise Jones, Kairbaan Hodivala-Dilke |
Abstract |
Breast cancer is a heterogeneous disease that can be classified into one of 4 main molecular sub-types: luminal A, luminal B, Her2 over-expressing and basal-like (BL). These tumour sub-types require different treatments and have different risks of disease progression. BL cancers can be considered a sub-group of Triple negative (TN) cancers since they lack estrogen (ER), progesterone (PR) and Her2 expression. No targeted treatment currently exists for TN/BL cancers. Thus it is important to identify potential therapeutic targets and describe their relationship with established prognostic factors. Focal adhesion kinase (FAK) is upregulated in several human cancers and also plays a functional role in tumour angiogenesis. However, the association between breast cancer sub-types and tumour endothelial-FAK expression is unknown. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 45% |
Researcher | 5 | 17% |
Student > Bachelor | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Other | 1 | 3% |
Other | 2 | 7% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 31% |
Biochemistry, Genetics and Molecular Biology | 7 | 24% |
Medicine and Dentistry | 5 | 17% |
Immunology and Microbiology | 1 | 3% |
Computer Science | 1 | 3% |
Other | 2 | 7% |
Unknown | 4 | 14% |