Title |
Contribution of genetic variation to transgenerational inheritance of DNA methylation
|
---|---|
Published in |
Genome Biology, May 2014
|
DOI | 10.1186/gb-2014-15-5-r73 |
Pubmed ID | |
Authors |
Allan F McRae, Joseph E Powell, Anjali K Henders, Lisa Bowdler, Gibran Hemani, Sonia Shah, Jodie N Painter, Nicholas G Martin, Peter M Visscher, Grant W Montgomery |
Abstract |
Despite the important role DNA methylation plays in transcriptional regulation, the transgenerational inheritance of DNA methylation is not well understood. The genetic heritability of DNA methylation has been estimated using twin pairs, although concern has been expressed whether the underlying assumption of equal common environmental effects are applicable due to intrauterine differences between monozygotic and dizygotic twins. We estimate the heritability of DNA methylation on peripheral blood leukocytes using Illumina HumanMethylation450 array using a family based sample of 614 people from 117 families, allowing comparison both within and across generations. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 44 | 32% |
United Kingdom | 19 | 14% |
Australia | 7 | 5% |
Switzerland | 5 | 4% |
France | 4 | 3% |
Canada | 3 | 2% |
Spain | 3 | 2% |
Finland | 2 | 1% |
Tunisia | 1 | <1% |
Other | 9 | 7% |
Unknown | 41 | 30% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 69 | 50% |
Scientists | 53 | 38% |
Practitioners (doctors, other healthcare professionals) | 9 | 7% |
Science communicators (journalists, bloggers, editors) | 7 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
Switzerland | 2 | <1% |
Turkey | 1 | <1% |
France | 1 | <1% |
Germany | 1 | <1% |
Canada | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
New Zealand | 1 | <1% |
Other | 0 | 0% |
Unknown | 243 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 75 | 29% |
Researcher | 66 | 26% |
Student > Master | 21 | 8% |
Student > Doctoral Student | 19 | 7% |
Professor | 12 | 5% |
Other | 40 | 16% |
Unknown | 23 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 106 | 41% |
Biochemistry, Genetics and Molecular Biology | 60 | 23% |
Medicine and Dentistry | 19 | 7% |
Computer Science | 10 | 4% |
Psychology | 10 | 4% |
Other | 21 | 8% |
Unknown | 30 | 12% |