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Biological function in the twilight zone of sequence conservation

Overview of attention for article published in BMC Biology, August 2017
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1 news outlet
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1 blog
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48 X users

Citations

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108 Mendeley
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3 CiteULike
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Title
Biological function in the twilight zone of sequence conservation
Published in
BMC Biology, August 2017
DOI 10.1186/s12915-017-0411-5
Pubmed ID
Authors

Chris P. Ponting

Abstract

Strong DNA conservation among divergent species is an indicator of enduring functionality. With weaker sequence conservation we enter a vast 'twilight zone' in which sequence subject to transient or lower constraint cannot be distinguished easily from neutrally evolving, non-functional sequence. Twilight zone functional sequence is illuminated instead by principles of selective constraint and positive selection using genomic data acquired from within a species' population. Application of these principles reveals that despite being biochemically active, most twilight zone sequence is not functional.

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X Demographics

The data shown below were collected from the profiles of 48 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 108 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 22%
Researcher 18 17%
Student > Bachelor 12 11%
Student > Master 10 9%
Student > Doctoral Student 6 6%
Other 24 22%
Unknown 14 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 40 37%
Agricultural and Biological Sciences 35 32%
Medicine and Dentistry 3 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Mathematics 2 2%
Other 8 7%
Unknown 18 17%