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PEG-ing down (and preventing?) the cause of pegloticase failure

Overview of attention for article published in Arthritis Research & Therapy, May 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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1 X user
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13 patents

Citations

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2 Dimensions

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5 Mendeley
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Title
PEG-ing down (and preventing?) the cause of pegloticase failure
Published in
Arthritis Research & Therapy, May 2014
DOI 10.1186/ar4572
Pubmed ID
Authors

Aryeh M Abeles

Abstract

Pegloticase is a powerful but underutilized weapon in the rheumatologist's armamentarium. The drug's immunogenicity leads to neutralizing antibody formation and rapid loss of efficacy in roughly one-half of all patients, which remains an impediment to broader use. New data, however, suggest that drug survival might improve with concomitant immunosuppressive agent (s), which merits further study. Efficacy appears to be unchanged when pegloticase is infused at 3-week (rather than 2-week) intervals. Stretching the time between infusions may also improve patient adherence and allow for earlier identification of transient responders.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 20%
Unknown 4 80%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 60%
Other 1 20%
Unknown 1 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 20%
Physics and Astronomy 1 20%
Chemistry 1 20%
Medicine and Dentistry 1 20%
Unknown 1 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2023.
All research outputs
#7,959,659
of 25,371,288 outputs
Outputs from Arthritis Research & Therapy
#1,612
of 3,381 outputs
Outputs of similar age
#71,859
of 240,670 outputs
Outputs of similar age from Arthritis Research & Therapy
#10
of 41 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,670 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.