Title |
The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia
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Published in |
Arthritis Research & Therapy, April 2011
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DOI | 10.1186/ar3306 |
Pubmed ID | |
Authors |
Yvonne C Lee, Nicholas J Nassikas, Daniel J Clauw |
Abstract |
Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) is well documented. A few studies have also noted alterations in central pain processing in osteoarthritis, and some data, including the observation of widespread pain sensitivity, suggest that central pain-processing defects may alter the pain response in rheumatoid arthritis patients. When central pain is identified, different classes of analgesics (for example, serotonin-norepinephrine reuptake inhibitors, α2δ ligands) may be more effective than drugs that treat peripheral or nociceptive pain (for example, nonsteroidal anti-inflammatory drugs and opioids). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 1% |
Brazil | 2 | <1% |
Portugal | 1 | <1% |
Mexico | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 354 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 50 | 14% |
Student > Master | 49 | 13% |
Researcher | 43 | 12% |
Student > Bachelor | 39 | 11% |
Other | 27 | 7% |
Other | 75 | 21% |
Unknown | 81 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 132 | 36% |
Nursing and Health Professions | 33 | 9% |
Psychology | 24 | 7% |
Agricultural and Biological Sciences | 21 | 6% |
Neuroscience | 20 | 5% |
Other | 43 | 12% |
Unknown | 91 | 25% |