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Analysing GCN4 translational control in yeast by stochastic chemical kinetics modelling and simulation

Overview of attention for article published in BMC Systems Biology, August 2011
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  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

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2 tweeters

Citations

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14 Dimensions

Readers on

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53 Mendeley
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Title
Analysing GCN4 translational control in yeast by stochastic chemical kinetics modelling and simulation
Published in
BMC Systems Biology, August 2011
DOI 10.1186/1752-0509-5-131
Pubmed ID
Authors

Tao You, Ian Stansfield, M Carmen Romano, Alistair JP Brown, George M Coghill

Abstract

The yeast Saccharomyces cerevisiae responds to amino acid starvation by inducing the transcription factor Gcn4. This is mainly mediated via a translational control mechanism dependent upon the translation initiation eIF2·GTP·Met-tRNAiMet ternary complex, and the four short upstream open reading frames (uORFs) in its 5' mRNA leader. These uORFs act to attenuate GCN4 mRNA translation under normal conditions. During amino acid starvation, levels of ternary complex are reduced. This overcomes the GCN4 translation attenuation effect via a scanning/reinitiation control mechanism dependent upon uORF spacing.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
United Kingdom 1 2%
Canada 1 2%
Unknown 49 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 32%
Student > Ph. D. Student 14 26%
Student > Master 6 11%
Student > Doctoral Student 4 8%
Student > Bachelor 3 6%
Other 3 6%
Unknown 6 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 53%
Biochemistry, Genetics and Molecular Biology 6 11%
Mathematics 2 4%
Medicine and Dentistry 2 4%
Engineering 2 4%
Other 6 11%
Unknown 7 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2011.
All research outputs
#2,328,211
of 4,505,992 outputs
Outputs from BMC Systems Biology
#308
of 670 outputs
Outputs of similar age
#26,425
of 60,808 outputs
Outputs of similar age from BMC Systems Biology
#11
of 39 outputs
Altmetric has tracked 4,505,992 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 670 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 60,808 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.