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Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons

Overview of attention for article published in Journal of Neuroinflammation, March 2014
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Title
Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons
Published in
Journal of Neuroinflammation, March 2014
DOI 10.1186/1742-2094-11-60
Pubmed ID
Authors

Leigh Wellhauser, Denise D Belsham

Abstract

Overnutrition and the ensuing hypothalamic inflammation is a major perpetuating factor in the development of metabolic diseases, such as obesity and diabetes. Inflamed neurons of the CNS fail to properly regulate energy homeostasis leading to pathogenic changes in glucose handling, feeding, and body weight. Hypothalamic neurons are particularly sensitive to pro-inflammatory signals derived locally and peripherally, and it is these neurons that become inflamed first upon high fat feeding. Given the prevalence of metabolic disease, efforts are underway to identify therapeutic targets for this inflammatory state. At least in the periphery, omega-3 fatty acids and their receptor, G-protein coupled receptor 120 (GPR120), have emerged as putative targets. The role for GPR120 in the hypothalamus or CNS in general is poorly understood.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
Unknown 84 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 15%
Student > Master 12 14%
Student > Bachelor 12 14%
Student > Ph. D. Student 10 12%
Other 4 5%
Other 15 17%
Unknown 20 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 23%
Biochemistry, Genetics and Molecular Biology 10 12%
Medicine and Dentistry 9 10%
Pharmacology, Toxicology and Pharmaceutical Science 8 9%
Nursing and Health Professions 4 5%
Other 12 14%
Unknown 23 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2014.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Journal of Neuroinflammation
#2,605
of 2,951 outputs
Outputs of similar age
#207,278
of 238,079 outputs
Outputs of similar age from Journal of Neuroinflammation
#42
of 44 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,951 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,079 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.