Title |
Inorganic polyphosphate regulates neuronal excitability through modulation of voltage-gated channels
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Published in |
Molecular Brain, May 2014
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DOI | 10.1186/1756-6606-7-42 |
Pubmed ID | |
Authors |
Stephanie C Stotz, Lucas OM Scott, Christopher Drummond-Main, Yosef Avchalumov, Fernando Girotto, Jörn Davidsen, Maria R Gómez-Gárcia, Jong M Rho, Evgeny V Pavlov, Michael A Colicos |
Abstract |
Inorganic polyphosphate (polyP) is a highly charged polyanion capable of interacting with a number of molecular targets. This signaling molecule is released into the extracellular matrix by central astrocytes and by peripheral platelets during inflammation. While the release of polyP is associated with both induction of blood coagulation and astrocyte extracellular signaling, the role of secreted polyP in regulation of neuronal activity remains undefined. Here we test the hypothesis that polyP is an important participant in neuronal signaling. Specifically, we investigate the ability of neurons to release polyP and to induce neuronal firing, and clarify the underlying molecular mechanisms of this process by studying the action of polyP on voltage gated channels. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 22% |
Researcher | 8 | 20% |
Student > Bachelor | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Student > Postgraduate | 3 | 7% |
Other | 5 | 12% |
Unknown | 9 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 24% |
Agricultural and Biological Sciences | 7 | 17% |
Neuroscience | 7 | 17% |
Medicine and Dentistry | 3 | 7% |
Chemistry | 2 | 5% |
Other | 2 | 5% |
Unknown | 10 | 24% |