Title |
An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer
|
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Published in |
Breast Cancer Research, June 2014
|
DOI | 10.1186/bcr3668 |
Pubmed ID | |
Authors |
Misako Sato, Mitsutaka Kadota, Binwu Tang, Howard H Yang, Yu-an Yang, Mengge Shan, Jia Weng, Michael A Welsh, Kathleen C Flanders, Yoshiko Nagano, Aleksandra M Michalowski, Robert J Clifford, Maxwell P Lee, Lalage M Wakefield |
Abstract |
Transforming growth factor-betas (TGF-betas) play a dual role in breast cancer, with context-dependent tumor suppressive or pro-oncogenic effects. TGF-beta antagonists are showing promise in early phase clinical oncology trials to neutralize the pro-oncogenic effects. However, there is currently no way to determine whether the tumor suppressive effects of TGF-beta are still active in human breast tumors at the time of surgery and treatment, a situation that could lead to adverse therapeutic responses. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 67% |
France | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
United States | 1 | 2% |
China | 1 | 2% |
France | 1 | 2% |
Unknown | 39 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 28% |
Researcher | 11 | 26% |
Student > Bachelor | 5 | 12% |
Student > Master | 3 | 7% |
Student > Doctoral Student | 2 | 5% |
Other | 7 | 16% |
Unknown | 3 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 30% |
Medicine and Dentistry | 7 | 16% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Nursing and Health Professions | 2 | 5% |
Other | 7 | 16% |
Unknown | 6 | 14% |