Title |
Short-term mechanical stretch fails to differentiate human adipose-derived stem cells into cardiovascular cell phenotypes
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Published in |
BioMedical Engineering OnLine, May 2014
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DOI | 10.1186/1475-925x-13-54 |
Pubmed ID | |
Authors |
Thais Girão-Silva, Vinicius Bassaneze, Luciene Cristina Gastalho Campos, Valerio Garrone Barauna, Luis Alberto Oliveira Dallan, Jose Eduardo Krieger, Ayumi Aurea Miyakawa |
Abstract |
We and others have previously demonstrated that adipose-derived stem cells (ASCs) transplantation improve cardiac dysfunction post-myocardium infarction (MI) under hemodynamic stress in rats. The beneficial effects appear to be associated with pleiotropic factors due to a complex interplay between the transplanted ASCs and the microenvironment in the absence of cell transdifferentiation. In the present work, we tested the hypothesis that mechanical stretch per se could change human ASCs (hASCs) into cardiovascular cell phenotypes that might influence post-MI outcomes. |
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