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Degeneration of penicillin production in ethanol-limited chemostat cultivations of Penicillium chrysogenum: A systems biology approach

Overview of attention for article published in BMC Systems Biology, August 2011
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1 tweeter

Citations

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Title
Degeneration of penicillin production in ethanol-limited chemostat cultivations of Penicillium chrysogenum: A systems biology approach
Published in
BMC Systems Biology, August 2011
DOI 10.1186/1752-0509-5-132
Pubmed ID
Authors

Rutger D Douma, Joana M Batista, Kai M Touw, Jan AKW Kiel, Arjen M Krikken, Zheng Zhao, Tânia Veiga, Paul Klaassen, Roel AL Bovenberg, Jean-Marc Daran, Joseph J Heijnen, Walter M van Gulik

Abstract

In microbial production of non-catabolic products such as antibiotics a loss of production capacity upon long-term cultivation (for example chemostat), a phenomenon called strain degeneration, is often observed. In this study a systems biology approach, monitoring changes from gene to produced flux, was used to study degeneration of penicillin production in a high producing Penicillium chrysogenum strain during prolonged ethanol-limited chemostat cultivations.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 49 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 20%
Student > Master 9 18%
Researcher 7 14%
Other 4 8%
Student > Bachelor 3 6%
Other 5 10%
Unknown 12 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 34%
Biochemistry, Genetics and Molecular Biology 9 18%
Engineering 5 10%
Chemical Engineering 2 4%
Unspecified 1 2%
Other 2 4%
Unknown 14 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2011.
All research outputs
#15,055,021
of 18,796,975 outputs
Outputs from BMC Systems Biology
#816
of 1,127 outputs
Outputs of similar age
#86,273
of 105,373 outputs
Outputs of similar age from BMC Systems Biology
#10
of 15 outputs
Altmetric has tracked 18,796,975 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,127 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,373 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.