Title |
Stilbenes and resveratrol metabolites improve mitochondrial fatty acid oxidation defects in human fibroblasts
|
---|---|
Published in |
Orphanet Journal of Rare Diseases, June 2014
|
DOI | 10.1186/1750-1172-9-79 |
Pubmed ID | |
Authors |
Virginie Aires, Dominique Delmas, Carole Le Bachelier, Norbert Latruffe, Dimitri Schlemmer, Jean-François Benoist, Fatima Djouadi, Jean Bastin |
Abstract |
Inborn enzyme defects of mitochondrial fatty acid beta-oxidation (FAO) form a large group of genetic disorders associated to variable clinical presentations ranging from life-threatening pediatric manifestations up to milder late onset phenotypes, including myopathy. Very few candidate drugs have been identified in this group of disorders. Resveratrol (RSV) is a natural polyphenol with anti-oxidant and anti-inflammatory effects, recently shown to have beneficial metabolic properties in mice models. Our study explores its possible effects on FAO and mitochondrial energy metabolism in human cells, which are still very little documented. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 18% |
Student > Ph. D. Student | 6 | 15% |
Researcher | 5 | 13% |
Other | 4 | 10% |
Student > Master | 4 | 10% |
Other | 6 | 15% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 33% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Chemistry | 4 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Mathematics | 1 | 3% |
Other | 4 | 10% |
Unknown | 10 | 25% |