Title |
Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus
|
---|---|
Published in |
Molecular Brain, June 2014
|
DOI | 10.1186/1756-6606-7-44 |
Pubmed ID | |
Authors |
Yuichiro Hayashi, Yoko Nabeshima, Katsunori Kobayashi, Tsuyoshi Miyakawa, Koichi Tanda, Keizo Takao, Hidenori Suzuki, Eisaku Esumi, Shigeru Noguchi, Yukiko Matsuda, Toshikuni Sasaoka, Tetsuo Noda, Jun-ichi Miyazaki, Masayoshi Mishina, Kazuo Funabiki, Yo-ichi Nabeshima |
Abstract |
Voltage-dependent block of the NMDA receptor by Mg2+ is thought to be central to the unique involvement of this receptor in higher brain functions. However, the in vivo role of the Mg2+ block in the mammalian brain has not yet been investigated, because brain-wide loss of the Mg2+ block causes perinatal lethality. In this study, we used a brain-region specific knock-in mouse expressing an NMDA receptor that is defective for the Mg2+ block in order to test its role in neural information processing. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 3% |
France | 1 | 3% |
Unknown | 30 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 28% |
Student > Ph. D. Student | 5 | 16% |
Student > Master | 4 | 13% |
Other | 4 | 13% |
Student > Doctoral Student | 2 | 6% |
Other | 5 | 16% |
Unknown | 3 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 10 | 31% |
Agricultural and Biological Sciences | 5 | 16% |
Psychology | 4 | 13% |
Medicine and Dentistry | 3 | 9% |
Engineering | 2 | 6% |
Other | 4 | 13% |
Unknown | 4 | 13% |