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Mesenchymal stem cell therapy for attenuation of scar formation during wound healing

Overview of attention for article published in Stem Cell Research & Therapy, May 2012
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1 Google+ user

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230 Mendeley
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Title
Mesenchymal stem cell therapy for attenuation of scar formation during wound healing
Published in
Stem Cell Research & Therapy, May 2012
DOI 10.1186/scrt111
Pubmed ID
Authors

Wesley M Jackson, Leon J Nesti, Rocky S Tuan

Abstract

Scars are a consequence of cutaneous wound healing that can be both unsightly and detrimental to the function of the tissue. Scar tissue is generated by excessive deposition of extracellular matrix tissue by wound healing fibroblasts and myofibroblasts, and although it is inferior to the uninjured skin, it is able to restore integrity to the boundary between the body and its environment. Scarring is not a necessary process to repair the dermal tissues. Rather, scar tissue forms due to specific mechanisms that occur during the adult wound healing process and are modulated primarily by the inflammatory response at the site of injury. Adult tissue-derived mesenchymal stem cells, which participate in normal wound healing, are trophic mediators of tissue repair. These cells participate in attenuating inflammation in the wound and reprogramming the resident immune and wound healing cells to favor tissue regeneration and inhibit fibrotic tissue formation. As a result, these cells have been considered and tested as a likely candidate for a cellular therapy to promote scar-less wound healing. This review identifies specific mechanisms by which mesenchymal stem cells can limit tissue fibrosis and summarizes recent in vivo studies where these cells have been used successfully to limit scar formation.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 230 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Sweden 1 <1%
China 1 <1%
Unknown 227 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 36 16%
Student > Master 36 16%
Researcher 29 13%
Student > Bachelor 23 10%
Student > Doctoral Student 17 7%
Other 49 21%
Unknown 40 17%
Readers by discipline Count As %
Medicine and Dentistry 46 20%
Biochemistry, Genetics and Molecular Biology 41 18%
Agricultural and Biological Sciences 40 17%
Engineering 13 6%
Pharmacology, Toxicology and Pharmaceutical Science 7 3%
Other 29 13%
Unknown 54 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2014.
All research outputs
#15,301,754
of 22,757,090 outputs
Outputs from Stem Cell Research & Therapy
#1,335
of 2,415 outputs
Outputs of similar age
#104,862
of 165,268 outputs
Outputs of similar age from Stem Cell Research & Therapy
#8
of 10 outputs
Altmetric has tracked 22,757,090 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,415 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,268 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.