Title |
Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
|
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Published in |
Diagnostic Pathology, June 2014
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DOI | 10.1186/1746-1596-9-111 |
Pubmed ID | |
Authors |
Michiyuki Hakozaki, Takahiro Tajino, Hitoshi Yamada, Osamu Hasegawa, Kazuhiro Tasaki, Kazuo Watanabe, Shinichi Konno |
Abstract |
We describe a case of giant cell tumor of the proximal tibia with skip bone metastases of the ipsilateral femur in a 20-year-old man. After the neoadjuvant treatment with denosumab, plain radiographs and computed tomography showed marked osteosclerosis and sclerotic rim formation, and 18F-FDG PET/CT showed a decreased standardized uptake value, whereas magnetic resonance imaging showed diffuse enhancement of the tumor, nearly the same findings as those at pretreatment. Pathological findings of the surgical specimen after the denosumab treatment showed benign fibrous histiocytoma-like features with complete disappearance of both mononuclear stromal cells and multinuclear osteoclast-like giant cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 6 | 13% |
Other | 5 | 11% |
Professor > Associate Professor | 5 | 11% |
Student > Master | 5 | 11% |
Student > Bachelor | 3 | 6% |
Other | 11 | 23% |
Unknown | 12 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 30 | 64% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Nursing and Health Professions | 1 | 2% |
Unknown | 14 | 30% |