↓ Skip to main content

3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders

Overview of attention for article published in Journal of Biomedical Science, August 2017
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#31 of 783)
  • High Attention Score compared to outputs of the same age (86th percentile)

Mentioned by

blogs
1 blog
twitter
9 tweeters
facebook
2 Facebook pages
wikipedia
2 Wikipedia pages
video
1 video uploader

Citations

dimensions_citation
56 Dimensions

Readers on

mendeley
378 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders
Published in
Journal of Biomedical Science, August 2017
DOI 10.1186/s12929-017-0362-8
Pubmed ID
Authors

Chun-Ting Lee, Raphael M. Bendriem, Wells W. Wu, Rong-Fong Shen

Abstract

Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), appear to recapitulate the brain's 3D cytoarchitectural arrangement and provide new opportunities to explore disease pathogenesis in the human brain. Human iPSC (hiPSC) reprogramming methods, combined with 3D brain organoid tools, may allow patient-derived organoids to serve as a preclinical platform to bridge the translational gap between animal models and human clinical trials. Studies using patient-derived brain organoids have already revealed novel insights into molecular and genetic mechanisms of certain complex human neurological disorders such as microcephaly, autism, and Alzheimer's disease. Furthermore, the combination of hiPSC technology and small-molecule high-throughput screening (HTS) facilitates the development of novel pharmacotherapeutic strategies, while transcriptome sequencing enables the transcriptional profiling of patient-derived brain organoids. Finally, the addition of CRISPR/Cas9 genome editing provides incredible potential for personalized cell replacement therapy with genetically corrected hiPSCs. This review describes the history and current state of 3D brain organoid differentiation strategies, a survey of applications of organoids towards studies of neurodevelopmental and neurodegenerative disorders, and the challenges associated with their use as in vitro models of neurological disorders.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 378 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 378 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 74 20%
Student > Ph. D. Student 68 18%
Student > Bachelor 60 16%
Researcher 47 12%
Student > Doctoral Student 23 6%
Other 42 11%
Unknown 64 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 80 21%
Neuroscience 75 20%
Agricultural and Biological Sciences 50 13%
Medicine and Dentistry 28 7%
Engineering 25 7%
Other 42 11%
Unknown 78 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2020.
All research outputs
#1,451,027
of 16,649,729 outputs
Outputs from Journal of Biomedical Science
#31
of 783 outputs
Outputs of similar age
#36,539
of 275,986 outputs
Outputs of similar age from Journal of Biomedical Science
#1
of 1 outputs
Altmetric has tracked 16,649,729 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 783 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,986 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them