Title |
Efficacy of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy, Mansa, Zambia
|
---|---|
Published in |
Malaria Journal, June 2014
|
DOI | 10.1186/1475-2875-13-227 |
Pubmed ID | |
Authors |
Kathrine R Tan, Bonnie L Katalenich, Kimberly E Mace, Michael Nambozi, Steve M Taylor, Steven R Meshnick, Ryan E Wiegand, Victor Chalwe, Scott J Filler, Mulakwa Kamuliwo, Allen S Craig |
Abstract |
Intermittent preventive treatment of malaria in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) decreases adverse effects of malaria during pregnancy. Zambia implemented its IPTp-SP programme in 2003. Emergence of SP-resistant Plasmodium falciparum threatens this strategy. The quintuple mutant haplotype (substitutions in N51I, C59R, S108N in dhfr and A437G and K540E in dhps genes), is associated with SP treatment failure in non-pregnant patients with malaria. This study examined efficacy of IPTp-SP and presence of the quintuple mutant among pregnant women in Mansa, Zambia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Unknown | 154 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 41 | 26% |
Student > Ph. D. Student | 17 | 11% |
Researcher | 16 | 10% |
Student > Bachelor | 15 | 10% |
Student > Postgraduate | 10 | 6% |
Other | 26 | 17% |
Unknown | 30 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 44 | 28% |
Biochemistry, Genetics and Molecular Biology | 15 | 10% |
Nursing and Health Professions | 15 | 10% |
Agricultural and Biological Sciences | 14 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 7% |
Other | 21 | 14% |
Unknown | 35 | 23% |