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Exosomal miRNAs as potential biomarkers of cardiovascular risk in children

Overview of attention for article published in Journal of Translational Medicine, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)

Mentioned by

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1 tweeter
patent
2 patents
googleplus
1 Google+ user

Citations

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81 Dimensions

Readers on

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158 Mendeley
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Title
Exosomal miRNAs as potential biomarkers of cardiovascular risk in children
Published in
Journal of Translational Medicine, January 2014
DOI 10.1186/1479-5876-12-162
Pubmed ID
Authors

Abdelnaby Khalyfa, David Gozal

Abstract

Intercellular interactions are essential for basic cellular activities and errors in either receiving or transferring these signals have shown to cause pathological conditions. These signals are not only regulated by membrane surface molecules but also by soluble secreted proteins, thereby allowing for an exquisite coordination of cell functions. Exosomes are released by cells upon fusion of multivesicular bodies (MVB) with the plasma membrane. Their envelope reflects their cellular origin and their surface and internal contents include important signaling components. Exosomes contain a wide variety of proteins, lipids, RNAs, non-transcribed RNAs, miRNAs and small RNAs that are representative to their cellular origin and shuttle from donor cells to recipient cells. The exosome formation cargo content and delivery is of immense biological interest because exosomes are believed to play major roles in various pathological conditions, and therefore provide unique opportunities for biomarker discovery and development of non-invasive diagnostics when examined in biological fluids such as urine and blood plasma. For example, circulating miRNAs in exosomes have been applied as functional biomarkers for diagnosis and outcomes prediction, while synthetic miRNAs in polymer-based nanoparticles are applicable for therapeutics. This review provides insights into the composition and functional properties of exosomes, and focuses on their potential value as diagnostic markers in the context of cardiovascular disease risk estimates in children who suffer from conditions associated with heightened prevalence of adverse cardiovascular disease, namely obesity and sleep-disordered-breathing.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 2 1%
Spain 2 1%
Russia 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 151 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 13%
Student > Master 21 13%
Researcher 20 13%
Student > Bachelor 16 10%
Professor > Associate Professor 13 8%
Other 45 28%
Unknown 22 14%
Readers by discipline Count As %
Medicine and Dentistry 42 27%
Agricultural and Biological Sciences 36 23%
Biochemistry, Genetics and Molecular Biology 30 19%
Engineering 4 3%
Nursing and Health Professions 3 2%
Other 17 11%
Unknown 26 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2020.
All research outputs
#3,115,550
of 17,648,139 outputs
Outputs from Journal of Translational Medicine
#480
of 3,246 outputs
Outputs of similar age
#34,897
of 197,875 outputs
Outputs of similar age from Journal of Translational Medicine
#1
of 1 outputs
Altmetric has tracked 17,648,139 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,246 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,875 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them