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Exosomal miRNAs as potential biomarkers of cardiovascular risk in children

Overview of attention for article published in Journal of Translational Medicine, June 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

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1 X user
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2 patents
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1 Google+ user

Citations

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102 Dimensions

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170 Mendeley
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Title
Exosomal miRNAs as potential biomarkers of cardiovascular risk in children
Published in
Journal of Translational Medicine, June 2014
DOI 10.1186/1479-5876-12-162
Pubmed ID
Authors

Abdelnaby Khalyfa, David Gozal

Abstract

Intercellular interactions are essential for basic cellular activities and errors in either receiving or transferring these signals have shown to cause pathological conditions. These signals are not only regulated by membrane surface molecules but also by soluble secreted proteins, thereby allowing for an exquisite coordination of cell functions. Exosomes are released by cells upon fusion of multivesicular bodies (MVB) with the plasma membrane. Their envelope reflects their cellular origin and their surface and internal contents include important signaling components. Exosomes contain a wide variety of proteins, lipids, RNAs, non-transcribed RNAs, miRNAs and small RNAs that are representative to their cellular origin and shuttle from donor cells to recipient cells. The exosome formation cargo content and delivery is of immense biological interest because exosomes are believed to play major roles in various pathological conditions, and therefore provide unique opportunities for biomarker discovery and development of non-invasive diagnostics when examined in biological fluids such as urine and blood plasma. For example, circulating miRNAs in exosomes have been applied as functional biomarkers for diagnosis and outcomes prediction, while synthetic miRNAs in polymer-based nanoparticles are applicable for therapeutics. This review provides insights into the composition and functional properties of exosomes, and focuses on their potential value as diagnostic markers in the context of cardiovascular disease risk estimates in children who suffer from conditions associated with heightened prevalence of adverse cardiovascular disease, namely obesity and sleep-disordered-breathing.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 2 1%
Spain 2 1%
Russia 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 163 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 14%
Researcher 22 13%
Student > Master 22 13%
Student > Bachelor 17 10%
Student > Doctoral Student 13 8%
Other 45 26%
Unknown 28 16%
Readers by discipline Count As %
Medicine and Dentistry 42 25%
Agricultural and Biological Sciences 36 21%
Biochemistry, Genetics and Molecular Biology 34 20%
Engineering 5 3%
Nursing and Health Professions 4 2%
Other 16 9%
Unknown 33 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2020.
All research outputs
#4,760,001
of 25,374,647 outputs
Outputs from Journal of Translational Medicine
#840
of 4,635 outputs
Outputs of similar age
#43,908
of 244,221 outputs
Outputs of similar age from Journal of Translational Medicine
#15
of 98 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,635 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,221 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.