Title |
Effects of camptothecin derivatives and topoisomerase dual inhibitors on Trypanosoma cruzi growth and ultrastructure
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Published in |
Journal of Negative Results in BioMedicine, June 2014
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DOI | 10.1186/1477-5751-13-11 |
Pubmed ID | |
Authors |
Otto Kischlat Lacombe, Aline Araujo Zuma, Camila Cristina da Silva, Wanderley de Souza, Maria Cristina M Motta |
Abstract |
Trypanosoma cruzi is the etiological agent of Chagas' disease that is an endemic disease in Latin America and affects about 8 million people. This parasite belongs to the Trypanosomatidae family which contains a single mitochondrion with an enlarged region, named kinetoplast that harbors the mitochondrial DNA (kDNA). The kinetoplast and the nucleus present a great variety of essential enzymes involved in DNA replication and topology, including DNA topoisomerases. Such enzymes are considered to be promising molecular targets for cancer treatment and for antiparasitic chemotherapy. In this work, the proliferation and ultrastructure of T. cruzi epimastigotes were evaluated after treatment with eukaryotic topoisomerase I inhibitors, such as topotecan and irinotecan, as well as with dual inhibitors (compounds that block eukaryotic topoisomerase I and topoisomerase II activities), such as baicalein, luteolin and evodiamine. Previous studies have shown that such inhibitors were able to block the growth of tumor cells, however most of them have never been tested on trypanosomatids. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 8 | 38% |
Researcher | 3 | 14% |
Professor | 2 | 10% |
Student > Master | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Other | 0 | 0% |
Unknown | 4 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 24% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 14% |
Medicine and Dentistry | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Other | 2 | 10% |
Unknown | 4 | 19% |