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Retinal and choroidal angiogenesis: a review of new targets

Overview of attention for article published in International Journal of Retina and Vitreous , August 2017
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  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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1 Facebook page

Citations

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114 Dimensions

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Title
Retinal and choroidal angiogenesis: a review of new targets
Published in
International Journal of Retina and Vitreous , August 2017
DOI 10.1186/s40942-017-0084-9
Pubmed ID
Authors

Thiago Cabral, Luiz Guilherme M. Mello, Luiz H. Lima, Júlia Polido, Caio V. Regatieri, Rubens Belfort, Vinit B. Mahajan

Abstract

Retinal and choroidal neovascularization are a major cause of significant visual impairment, worldwide. Understanding the various factors involved in the accompanying physiopathology is vital for development of novel treatments, and most important, for preserving patient vision. The intraocular use of anti-vascular endothelial growth factor therapeutics has improved management of the retinal and choroidal neovascularization but some patients do not respond, suggesting other vascular mediators may also contribute to ocular angiogenesis. Several recent studies examined possible new targets for future anti-angiogenic therapies. Potential targets of retinal and choroidal neovascularization therapy include members of the platelet-derived growth factor family, vascular endothelial growth factor sub-family, epidermal growth factor family, fibroblast growth factor family, transforming growth factor-β superfamily (TGF-β1, activins, follistatin and bone morphogenetic proteins), angiopoietin-like family, galectins family, integrin superfamily, as well as pigment epithelium derived factor, hepatocyte growth factor, angiopoietins, endothelins, hypoxia-inducible factors, insulin-like growth factors, cytokines, matrix metalloproteinases and their inhibitors and glycosylation proteins. This review highlights current antiangiogenic therapies under development, and discusses future retinal and choroidal pro- and anti-angiogenic targets as wells as the importance of developing of new drugs.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 116 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 15%
Student > Master 15 13%
Student > Doctoral Student 13 11%
Student > Bachelor 13 11%
Researcher 11 9%
Other 14 12%
Unknown 33 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 28 24%
Medicine and Dentistry 15 13%
Agricultural and Biological Sciences 9 8%
Pharmacology, Toxicology and Pharmaceutical Science 9 8%
Nursing and Health Professions 4 3%
Other 14 12%
Unknown 37 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2017.
All research outputs
#14,918,049
of 25,382,440 outputs
Outputs from International Journal of Retina and Vitreous
#72
of 262 outputs
Outputs of similar age
#164,372
of 325,576 outputs
Outputs of similar age from International Journal of Retina and Vitreous
#3
of 7 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 262 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,576 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.