Title |
Genome-wide association studies dissect the genetic networks underlying agronomical traits in soybean
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Published in |
Genome Biology, August 2017
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DOI | 10.1186/s13059-017-1289-9 |
Pubmed ID | |
Authors |
Chao Fang, Yanming Ma, Shiwen Wu, Zhi Liu, Zheng Wang, Rui Yang, Guanghui Hu, Zhengkui Zhou, Hong Yu, Min Zhang, Yi Pan, Guoan Zhou, Haixiang Ren, Weiguang Du, Hongrui Yan, Yanping Wang, Dezhi Han, Yanting Shen, Shulin Liu, Tengfei Liu, Jixiang Zhang, Hao Qin, Jia Yuan, Xiaohui Yuan, Fanjiang Kong, Baohui Liu, Jiayang Li, Zhiwu Zhang, Guodong Wang, Baoge Zhu, Zhixi Tian |
Abstract |
Soybean (Glycine max [L.] Merr.) is one of the most important oil and protein crops. Ever-increasing soybean consumption necessitates the improvement of varieties for more efficient production. However, both correlations among different traits and genetic interactions among genes that affect a single trait pose a challenge to soybean breeding. To understand the genetic networks underlying phenotypic correlations, we collected 809 soybean accessions worldwide and phenotyped them for two years at three locations for 84 agronomic traits. Genome-wide association studies identified 245 significant genetic loci, among which 95 genetically interacted with other loci. We determined that 14 oil synthesis-related genes are responsible for fatty acid accumulation in soybean and function in line with an additive model. Network analyses demonstrated that 51 traits could be linked through the linkage disequilibrium of 115 associated loci and these links reflect phenotypic correlations. We revealed that 23 loci, including the known Dt1, E2, E1, Ln, Dt2, Fan, and Fap loci, as well as 16 undefined associated loci, have pleiotropic effects on different traits. This study provides insights into the genetic correlation among complex traits and will facilitate future soybean functional studies and breeding through molecular design. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Malaysia | 1 | 7% |
Spain | 1 | 7% |
Canada | 1 | 7% |
United States | 1 | 7% |
United Kingdom | 1 | 7% |
Unknown | 10 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 8 | 53% |
Members of the public | 5 | 33% |
Science communicators (journalists, bloggers, editors) | 2 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 261 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 52 | 20% |
Researcher | 44 | 17% |
Student > Master | 25 | 10% |
Student > Doctoral Student | 13 | 5% |
Student > Bachelor | 8 | 3% |
Other | 30 | 11% |
Unknown | 89 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 130 | 50% |
Biochemistry, Genetics and Molecular Biology | 23 | 9% |
Psychology | 2 | <1% |
Computer Science | 2 | <1% |
Engineering | 2 | <1% |
Other | 7 | 3% |
Unknown | 95 | 36% |