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X Demographics
Mendeley readers
| Title |
BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex
|
|---|---|
| Published in |
BMC Biology, May 2014
|
| DOI | 10.1186/1741-7007-12-43 |
| Pubmed ID | |
| Authors |
Christian Hiepen, Andreas Benn, Agnieszka Denkis, Ilya Lukonin, Christoph Weise, Jan H Boergermann, Petra Knaus |
| Abstract |
BMP-induced chemotaxis of mesenchymal progenitors is fundamental for vertebrate development, disease and tissue repair. BMP2 induces Smad and non-Smad signaling. Whereas signal transduction via Smads lead to transcriptional responses, non-Smad signaling induces both, transcriptional and immediate/early non-transcriptional responses. However, the molecular mechanisms by which BMP2 facilitates planar cell polarity, cortical actin rearrangements, lamellipodia formation and chemotaxis of mesenchymal progenitors are poorly understood. Our aim was to uncover the molecular mechanism by which BMP2 facilitates chemotaxis via the BMP2-dependent activation of PI3K and spatiotemporal control of PIP3 production important for actin rearrangements at the mesenchymal cell cytocortex. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 46 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 21% |
| Student > Master | 9 | 19% |
| Researcher | 5 | 11% |
| Student > Bachelor | 4 | 9% |
| Professor > Associate Professor | 4 | 9% |
| Other | 4 | 9% |
| Unknown | 11 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 21% |
| Agricultural and Biological Sciences | 10 | 21% |
| Biochemistry, Genetics and Molecular Biology | 8 | 17% |
| Mathematics | 1 | 2% |
| Business, Management and Accounting | 1 | 2% |
| Other | 5 | 11% |
| Unknown | 12 | 26% |