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Adjudin protects against cerebral ischemia reperfusion injury by inhibition of neuroinflammation and blood-brain barrier disruption

Overview of attention for article published in Journal of Neuroinflammation, June 2014
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Mentioned by

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1 tweeter

Citations

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57 Dimensions

Readers on

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31 Mendeley
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Title
Adjudin protects against cerebral ischemia reperfusion injury by inhibition of neuroinflammation and blood-brain barrier disruption
Published in
Journal of Neuroinflammation, June 2014
DOI 10.1186/1742-2094-11-107
Pubmed ID
Authors

Tengyuan Liu, Tingting Zhang, Hemei Yu, Hailian Shen, Weiliang Xia

Abstract

Neuroinflammation mediated by activation of microglia and interruption of the blood-brain barrier (BBB) is an important factor that contributes to neuron death and infarct area diffusion in ischemia reperfusion injury. Finding novel molecules to regulate neuroinflammation is of significant clinical value. We have previously shown that adjudin, a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-kappaB pathway. In this study we continued to explore whether adjudin could be neuroprotective by using the transient middle cerebral artery occlusion (tMCAO) model. Adjudin treatment after reperfusion significantly decreased the infarction volume and neuroscore compared to the vehicle group. Staining of CD11b showed that adjudin markedly inhibited microglial activation in both the cortex and the striatum, accompanied by a reduction in the expression and release of cytokines TNF-alpha, IL-1beta and IL-6. Concomitantly, adjudin noticeably prevented BBB disruption after ischemia and reperfusion, as indicated by the reduction of IgG detection in the brain cortex and striatum versus the vehicle group. This finding was also corroborated by immunofluorescence staining and immunoblotting of tight junction-related proteins ZO-1, JAM-A and Occludin, where the reduction of these proteins could be attenuated by adjudin treatment. Moreover, adjudin obviously inhibited the elevated MMP-9 activity after stroke. Together these data demonstrate that adjudin protects against cerebral ischemia reperfusion injury, and we present an effective neuroinflammation modulator with clinical potential.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Canada 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 16%
Other 4 13%
Student > Master 4 13%
Student > Ph. D. Student 4 13%
Student > Bachelor 3 10%
Other 6 19%
Unknown 5 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 19%
Medicine and Dentistry 5 16%
Neuroscience 5 16%
Agricultural and Biological Sciences 4 13%
Engineering 2 6%
Other 3 10%
Unknown 6 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2014.
All research outputs
#2,346,398
of 4,505,617 outputs
Outputs from Journal of Neuroinflammation
#321
of 659 outputs
Outputs of similar age
#53,413
of 107,476 outputs
Outputs of similar age from Journal of Neuroinflammation
#13
of 28 outputs
Altmetric has tracked 4,505,617 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 659 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,476 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.