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A human-specific allelic group of the MHC DRB1 gene in primates

Overview of attention for article published in Journal of Physiological Anthropology, June 2014
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3 X users

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Title
A human-specific allelic group of the MHC DRB1 gene in primates
Published in
Journal of Physiological Anthropology, June 2014
DOI 10.1186/1880-6805-33-14
Pubmed ID
Authors

Yoshiki Yasukochi, Yoko Satta

Abstract

Diversity among human leukocyte antigen (HLA) molecules has been maintained by host-pathogen coevolution over a long period of time. Reflecting this diversity, the HLA loci are the most polymorphic in the human genome. One characteristic of HLA diversity is long-term persistence of allelic lineages, which causes trans-species polymorphisms to be shared among closely related species. Modern humans have disseminated across the world after their exodus from Africa, while chimpanzees have remained in Africa since the speciation event between humans and chimpanzees. It is thought that modern humans have recently acquired resistance to novel pathogens outside Africa. In the present study, we investigated HLA alleles that could contribute to this local adaptation in humans and also studied the contribution of natural selection to human evolution by using molecular data.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 4%
Germany 1 4%
Brazil 1 4%
Unknown 24 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 26%
Student > Master 5 19%
Student > Ph. D. Student 4 15%
Student > Doctoral Student 2 7%
Professor 2 7%
Other 2 7%
Unknown 5 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 44%
Biochemistry, Genetics and Molecular Biology 5 19%
Computer Science 1 4%
Immunology and Microbiology 1 4%
Unknown 8 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2014.
All research outputs
#14,600,553
of 25,374,647 outputs
Outputs from Journal of Physiological Anthropology
#220
of 451 outputs
Outputs of similar age
#117,695
of 243,420 outputs
Outputs of similar age from Journal of Physiological Anthropology
#7
of 13 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 451 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.4. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,420 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.