Title |
Resistin-induced stromal cell-derived factor-1 expression through Toll-like receptor 4 and activation of p38 MAPK/ NFκB signaling pathway in gastric cancer cells
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Published in |
Journal of Biomedical Science, June 2014
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DOI | 10.1186/1423-0127-21-59 |
Pubmed ID | |
Authors |
Yung-Yu Hsieh, Chien-Heng Shen, Wen-Shih Huang, Chih-Chien Chin, Yi-Hung Kuo, Meng Chiao Hsieh, Hong-Ren Yu, Te-Sheng Chang, Tseng-Hsi Lin, Yung-Wei Chiu, Cheng-Nan Chen, Hsing-Chun Kuo, Shui-Yi Tung |
Abstract |
Stromal cell-derived factor-1 (SDF-1) (CXC chemokine ligand-12) / CXC chemokine receptor 4 (CXCR4) is involved in the carcinogenesis of human gastric cancer, where it stimulates angiogenesis and favors metastasis of tumor cells to distant organs. In addition, resistin is suggested to be an important link between obesity and the development of gastric cancer. Resistin has identified as an important player in inflammatory responses, and emerged as a mediator in inflammation-associated cancer. A limited number of studies have investigated the association of resistin and SDF-1 with gastric cancer. Herein, we investigated the molecular mechanisms by which resistin influences the expression of SDF-1 in gastric carcinoma cells. |
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France | 1 | 100% |
Demographic breakdown
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Mendeley readers
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