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Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain

Overview of attention for article published in BMC Neuroscience, June 2014
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Title
Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain
Published in
BMC Neuroscience, June 2014
DOI 10.1186/1471-2202-15-74
Pubmed ID
Authors

William Spears, Matthew Furgerson, John Michael Sweetnam, Parker Evans, Marla Gearing, Marcus Fechheimer, Ruth Furukawa

Abstract

Hirano bodies are actin-rich paracrystalline inclusions found in brains of patients with Alzheimer's disease (AD), frontotemporal dementia (FTD), and in normal aged individuals. Although studies of post-mortem brain tissue provide clues of etiology, the physiological function of Hirano bodies remains unknown. A cell culture model was utilized to study the interactions of mutant tau proteins, model Hirano bodies, and GSK3beta in human astrocytoma cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 21%
Student > Bachelor 7 18%
Student > Doctoral Student 4 10%
Student > Master 4 10%
Other 3 8%
Other 7 18%
Unknown 6 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 23%
Neuroscience 7 18%
Agricultural and Biological Sciences 6 15%
Psychology 4 10%
Medicine and Dentistry 3 8%
Other 4 10%
Unknown 6 15%