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Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells

Overview of attention for article published in Molecular Cancer, July 2011
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Mentioned by

peer_reviews
1 peer review site

Citations

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43 Dimensions

Readers on

mendeley
49 Mendeley
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Title
Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells
Published in
Molecular Cancer, July 2011
DOI 10.1186/1476-4598-10-80
Pubmed ID
Authors

Agnes Basseville, Laurence Preisser, Sophie de Carné Trécesson, Michèle Boisdron-Celle, Erick Gamelin, Olivier Coqueret, Alain Morel

Abstract

Resistance to chemotherapy remains one of the principle obstacles to the treatment of colon cancer. In order to identify the molecular mechanism of this resistance, we investigated the role of the steroid and xenobiotic receptor (SXR) in the induction of drug resistance. Indeed, this nuclear receptor plays an important role in response to xenobiotics through the upregulation of detoxification genes. Following drug treatments, SXR is activated and interacts with the retinoid X receptor (RXR) to induce expression of some genes involved in drug metabolism such as phase I enzyme (like CYP), phase II enzymes (like UGT) and transporters (e.g. MDR1).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 22%
Researcher 9 18%
Student > Master 5 10%
Other 3 6%
Student > Bachelor 3 6%
Other 7 14%
Unknown 11 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 35%
Agricultural and Biological Sciences 14 29%
Medicine and Dentistry 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Immunology and Microbiology 1 2%
Other 1 2%
Unknown 10 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2014.
All research outputs
#15,301,754
of 22,757,090 outputs
Outputs from Molecular Cancer
#1,042
of 1,718 outputs
Outputs of similar age
#83,866
of 116,334 outputs
Outputs of similar age from Molecular Cancer
#10
of 15 outputs
Altmetric has tracked 22,757,090 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,718 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,334 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.