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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenetic regulation of asthma and allergic disease
|
|---|---|
| Published in |
Allergy, Asthma & Clinical Immunology, May 2014
|
| DOI | 10.1186/1710-1492-10-27 |
| Pubmed ID | |
| Authors |
Philippe Bégin, Kari C Nadeau |
| Abstract |
Epigenetics of asthma and allergic disease is a field that has expanded greatly in the last decade. Previously thought only in terms of cell differentiation, it is now evident the epigenetics regulate many processes. With T cell activation, commitment toward an allergic phenotype is tightly regulated by DNA methylation and histone modifications at the Th2 locus control region. When normal epigenetic control is disturbed, either experimentally or by environmental exposures, Th1/Th2 balance can be affected. Epigenetic marks are not only transferred to daughter cells with cell replication but they can also be inherited through generations. In animal models, with constant environmental pressure, epigenetically determined phenotypes are amplified through generations and can last up to 2 generations after the environment is back to normal. In this review on the epigenetic regulation of asthma and allergic diseases we review basic epigenetic mechanisms and discuss the epigenetic control of Th2 cells. We then cover the transgenerational inheritance model of epigenetic traits and discuss how this could relate the amplification of asthma and allergic disease prevalence and severity through the last decades. Finally, we discuss recent epigenetic association studies for allergic phenotypes and related environmental risk factors as well as potential underlying mechanisms for these associations. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 2 | 1% |
| France | 1 | <1% |
| Belgium | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 152 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 17% |
| Student > Bachelor | 25 | 16% |
| Student > Master | 19 | 12% |
| Student > Ph. D. Student | 18 | 11% |
| Student > Doctoral Student | 15 | 10% |
| Other | 23 | 15% |
| Unknown | 31 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 22% |
| Biochemistry, Genetics and Molecular Biology | 29 | 18% |
| Agricultural and Biological Sciences | 27 | 17% |
| Immunology and Microbiology | 12 | 8% |
| Environmental Science | 4 | 3% |
| Other | 14 | 9% |
| Unknown | 37 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2019.
All research outputs
#1,028,987
of 25,374,647 outputs
Outputs from Allergy, Asthma & Clinical Immunology
#49
of 924 outputs
Outputs of similar age
#9,831
of 241,293 outputs
Outputs of similar age from Allergy, Asthma & Clinical Immunology
#1
of 15 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 924 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,293 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.