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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T)mice
|
|---|---|
| Published in |
Molecular Neurodegeneration, June 2014
|
| DOI | 10.1186/1750-1326-9-24 |
| Pubmed ID | |
| Authors |
Sarah Herdewyn, Carla Cirillo, Ludo Van Den Bosch, Wim Robberecht, Pieter Vanden Berghe, Philip Van Damme |
| Abstract |
Intraneuronal inclusions of TAR DNA-binding protein 43 (TDP-43) have been found in the majority of Amyotrophic Lateral Sclerosis (ALS) patients. Mutations in the gene encoding TDP-43 cause familial ALS. Transgenic mice expressing mutant TDP-43 with one such mutation (TDP-43 (A315T)) under control of the murine prion promoter develop motor symptoms, but their use is currently hampered by sudden death. We aimed to understand and overcome the cause of sudden death in TDP-43 (A315T) mice. Since intestinal obstruction was suspected to be the cause, intestinal motility of TDP-43 (A315T) mice was studied in an ex-vivo pellet propulsion assay. The effect on the enteric and motor phenotype was assessed, both in animals on normal chow or on a jellified fiber deprived diet, aimed at preventing intestinal obstruction. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 85 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 17% |
| Researcher | 13 | 15% |
| Student > Master | 12 | 14% |
| Student > Doctoral Student | 7 | 8% |
| Professor > Associate Professor | 6 | 7% |
| Other | 15 | 17% |
| Unknown | 19 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 17 | 20% |
| Biochemistry, Genetics and Molecular Biology | 14 | 16% |
| Agricultural and Biological Sciences | 14 | 16% |
| Medicine and Dentistry | 13 | 15% |
| Psychology | 3 | 3% |
| Other | 5 | 6% |
| Unknown | 21 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2017.
All research outputs
#14,196,917
of 22,757,090 outputs
Outputs from Molecular Neurodegeneration
#679
of 846 outputs
Outputs of similar age
#120,010
of 228,185 outputs
Outputs of similar age from Molecular Neurodegeneration
#1
of 8 outputs
Altmetric has tracked 22,757,090 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 846 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,185 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them