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Hydroxybenzoic acid isomers and the cardiovascular system

Overview of attention for article published in Nutrition Journal, June 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Average Attention Score compared to outputs of the same age and source

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8 X users
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3 Facebook pages
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1 Wikipedia page

Citations

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117 Dimensions

Readers on

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173 Mendeley
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Title
Hydroxybenzoic acid isomers and the cardiovascular system
Published in
Nutrition Journal, June 2014
DOI 10.1186/1475-2891-13-63
Pubmed ID
Authors

Bernhard HJ Juurlink, Haya J Azouz, Alaa MZ Aldalati, Basmah MH AlTinawi, Paul Ganguly

Abstract

Today we are beginning to understand how phytochemicals can influence metabolism, cellular signaling and gene expression. The hydroxybenzoic acids are related to salicylic acid and salicin, the first compounds isolated that have a pharmacological activity. In this review we examine how a number of hydroxyphenolics have the potential to ameliorate cardiovascular problems related to aging such as hypertension, atherosclerosis and dyslipidemia. The compounds focused upon include 2,3-dihydroxybenzoic acid (Pyrocatechuic acid), 2,5-dihydroxybenzoic acid (Gentisic acid), 3,4-dihydroxybenzoic acid (Protocatechuic acid), 3,5-dihydroxybenzoic acid (α-Resorcylic acid) and 3-monohydroxybenzoic acid. The latter two compounds activate the hydroxycarboxylic acid receptors with a consequence there is a reduction in adipocyte lipolysis with potential improvements of blood lipid profiles. Several of the other compounds can activate the Nrf2 signaling pathway that increases the expression of antioxidant enzymes, thereby decreasing oxidative stress and associated problems such as endothelial dysfunction that leads to hypertension as well as decreasing generalized inflammation that can lead to problems such as atherosclerosis. It has been known for many years that increased consumption of fruits and vegetables promotes health. We are beginning to understand how specific phytochemicals are responsible for such therapeutic effects. Hippocrates' dictum of 'Let food be your medicine and medicine your food' can now be experimentally tested and the results of such experiments will enhance the ability of nutritionists to devise specific health-promoting diets.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 1 <1%
Unknown 172 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 13%
Student > Bachelor 18 10%
Student > Master 17 10%
Researcher 15 9%
Student > Doctoral Student 11 6%
Other 33 19%
Unknown 56 32%
Readers by discipline Count As %
Chemistry 20 12%
Agricultural and Biological Sciences 19 11%
Medicine and Dentistry 18 10%
Pharmacology, Toxicology and Pharmaceutical Science 16 9%
Biochemistry, Genetics and Molecular Biology 13 8%
Other 28 16%
Unknown 59 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2021.
All research outputs
#2,823,118
of 23,168,000 outputs
Outputs from Nutrition Journal
#602
of 1,439 outputs
Outputs of similar age
#29,035
of 229,102 outputs
Outputs of similar age from Nutrition Journal
#23
of 32 outputs
Altmetric has tracked 23,168,000 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,439 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.6. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,102 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.